Molecular mechanisms of motor neuron development and disease
See interview with Paschalis about directing the Center for Motor Neuron Disease (CMND)
Our Scientific Mission: Our lab uses the specific strengths of C. elegans, mice and human stem cell technology to reveal the molecular mechanisms that underlie motor neuron development and disease. We integrate genetic, genomic, and transcriptomic approaches with molecular and behavioral assays to illuminate the causative mechanisms of two neurological disorders: (a) the neurodevelopmental syndrome known as Hypotonia, Ataxia, and Delayed Development Syndrome (HADDS), and (b) the adult-onset neurodegenerative disease known as amyotrophic lateral sclerosis (ALS).
Educational mission of the lab: Our goal is to train the next-generation of scientists in an inspiring, inclusive and collaborative environment. Our lab condemns any kind of racism and discriminatory acts against all underrepresented groups in our scientific community, including, but not limited to, African Americans, Hispanic/Latino, women, LGBTQIA+, people with disabilities, those from different religious groups, and international scholars. We welcome trainees and scientists from any background to join our lab and thrive in an inclusive environment that values rigor, creativity, and respect.
Sydney Brenner, Nobel Prize, 2002 : "In one sense, all neurons resemble each other; they must be excitable, able to transmit electrical signals and produce and respond to chemical transmitters. They must be equipped with very similar, possibly commonly specified biochemical machinery. Yet, in another sense, they are all very different; cells are located at specific places and are connected to each other in definite ways. How is this complexity represented in the genetic program?"
Our Scientific Mission: Our lab uses the specific strengths of C. elegans, mice and human stem cell technology to reveal the molecular mechanisms that underlie motor neuron development and disease. We integrate genetic, genomic, and transcriptomic approaches with molecular and behavioral assays to illuminate the causative mechanisms of two neurological disorders: (a) the neurodevelopmental syndrome known as Hypotonia, Ataxia, and Delayed Development Syndrome (HADDS), and (b) the adult-onset neurodegenerative disease known as amyotrophic lateral sclerosis (ALS).
Educational mission of the lab: Our goal is to train the next-generation of scientists in an inspiring, inclusive and collaborative environment. Our lab condemns any kind of racism and discriminatory acts against all underrepresented groups in our scientific community, including, but not limited to, African Americans, Hispanic/Latino, women, LGBTQIA+, people with disabilities, those from different religious groups, and international scholars. We welcome trainees and scientists from any background to join our lab and thrive in an inclusive environment that values rigor, creativity, and respect.
Sydney Brenner, Nobel Prize, 2002 : "In one sense, all neurons resemble each other; they must be excitable, able to transmit electrical signals and produce and respond to chemical transmitters. They must be equipped with very similar, possibly commonly specified biochemical machinery. Yet, in another sense, they are all very different; cells are located at specific places and are connected to each other in definite ways. How is this complexity represented in the genetic program?"
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